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ISSN 1449-2288
International Journal of Medical Sciences
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Agricultural and Biological Sciences ...details
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| Systems capable of targeting genetic manipulations to keratin-
positive airway basal cells are more poorly developed than systems
targeting other airway epithelial cell populations and this has
likely hindered development of animal models of diseases such as lung
squamous cell carcinoma. In this issue, Malkoski et al. developed a
method for delivering RU486, the conditional activator of Cre
recombinase progesterone receptor (CrePR) fusion proteins to the lung
and then examined the activity of three keratin-driven CrePR
constructs in the conducting airways. Their data indicated that
K5Cre*PR is the most tightly regulated Cre driver making it ideal for
targeting somatic mutations to the airway epithelia while K5CrePR1
and K14CrePR1 may be better suited to studying diseases of the
conducting airways where gene targeting of keratin expressing cells
and their derivatives is desired.
Details ... |
Most Cited Paper Award for 2007: The winner was JK Lunney, for the paper Advances in Swine Biomedical Model Genomics (Cited by 49 as of Dec. 31, 2009). Details ... |
| Apolipoprotein A-I (apoA-I) mimetic peptides have been pursued as new
therapeutic agents for the treatment of atherosclerosis, yet their
precise mechanism responsible for atheroprotection remains unclear.
Song et al. compared a mimetic peptide D-4F to purified apoA-I and
found that D-4F particles were 20 times more efficient than apoA-I in
off-loading cholesterol to HepG2 hepatocytes. Furthermore, D-4F also
facilitated cholesteryl ester offloading from HDL particles into
HepG2 cells when it was pre-incubated with these HDL particles. Using
an inducible HEK293 cell line, they demonstrated that these nano-
particles were able to be taken up through SR-BI, a HDL selective
receptor. Cholesterol uptake by HepG2 cells was completely blocked by
a neutralizing monoclonal antibody against SR-BI, demonstrating that
D-4F particles, similar to HDL, specifically off-loaded cholesterol
through SR-BI.
More ... |
| Understanding the molecular basis of quantitative genetic variation
is a principal goal for biomedicine in human and genetic improvement
in agriculture species. However, identification of genes responsible
for the variation in complex phenotypes has been a challenge in
modern genetics. In the present study, Jiang et al pursued both
single marker-single trait association and multiple markers-single
trait regression analyses and revealed genetic networks associated
with economically important traits in beef cattle. Such genetic
networks involving both genotypes and quantitative trait modes (QTMs)
resulted in high correlations between predicted and actual values of
performance, thus providing evidence that the classical Mendelian
principals of inheritance can be applied in understanding genetic
complexity of complex phenotypes. More ... |
| Vertebrate Hox genes regulate many aspects of embryonic body plan
development and patterning. In this study, Hostikka et al generated
mice carrying a targeted mutation of Hoxc10, a member of the Hox10
paralogous family. Their data revealed a role for Hoxc10 in
generating or maintaining the normal complement of lumbar motor neurons.
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| The promyelocytic leukemia protein (PML) is involved in many cellular
processes including cell cycle progression, DNA damage response,
transcriptional regulation, viral infection, and apoptosis. These
cellular activities often rely on the localization of PML to unique
subnuclear structures known as PML nuclear bodies (NBs). More than 50
cellular proteins are known to traffic in and out of PML NBs, either
transiently or constitutively. In order to understand the dynamics of
these NBs, it is important to delineate the regulation of PML itself.
PML is subject to extensive regulation at transcriptional, post-
transcriptional, and post-translational levels. Many of these modes
of regulation depend on the cellular context and the presence of
extracellular signals. Here Reineke and Kao reviewed the current
knowledge of regulation of PML under normal cellular conditions as
well as the role for regulation of PML in viral infection and cancer.
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| Pulmonary fibrosis is an intractable paranchymal lung disease
characterized by persistent alveolitis, accumulation of connective
tissue and extracellular matrix, Here, Dr. Inage et al. investigated
the potential usefulness of vesnarinone, a novel cytokine inhibitor,
for the treatment of lung fibrosis using a murine model of bleomycin
(BLM)-induced pulmonary fibrosis. Their data indicated that dietary
intake of vesnarinone minimized the BLM toxicity as reflected by
significant decreases in numbers of inflammatory cells, KC, and
soluble TNF receptors in the bronchoalveolar lavage fluid. A
quantitative evaluation of histology demonstrated significantly mild
lung parenchymal lesions in BLM-treated mice fed with diet containing
high dose of vesnarinone than in the control diet group. Consistent
with the histopathology, hydroxyproline levels in lung tissue from
BLM-treated mice fed with diet containing vesnarinone were
significantly lower than that from mice fed with control diet. We
concluded that vesnarinone inhibits BLM-induced pulmonary fibrosis,
at least in part, by the inhibition of acute lung injuries in the
early phase.
More ... |
Overexpression of bacterial ethylene-forming enzyme gene in Trichoderma reesei enhanced the production of ethylene
Xi Chen, Yong Liang, Jing Hua, Li Tao, Wensheng Qin, Sanfeng Chen
Int. J. Biol. Sci. 2010, 6: 96-106
[Abstract]
[Full text]
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Comparative study of the binding pockets of mammalian proprotein convertases and its implications for the design of specific small molecule inhibitors
Sun Tian, Wu Jianhua
Int. J. Biol. Sci. 2010, 6: 89-95
[Abstract]
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Cellular and molecular comparison of redifferentiation of intramuscular- and visceral-adipocyte derived progeny cells
Jie Chen, Michael V. Dodson, Zhihua Jiang
Int. J. Biol. Sci. 2010, 6: 80-88
[Abstract]
[Full text]
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[PMC]
Keratin promoter based gene manipulation in the murine conducting airway
Stephen P. Malkoski, Timothy G. Cleaver, Shi-Long Lu, Jessyka G. Lighthall, Xiao-Jing Wang
Int. J. Biol. Sci. 2010, 6: 68-79
[Abstract]
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A manually curated network of the PML nuclear body interactome reveals an important role for PML-NBs in SUMOylation dynamics
Ellen Van Damme, Kris Laukens, Thanh Hai Dang, Xaveer Van Ostade
Int. J. Biol. Sci. 2010, 6: 51-67
[Abstract]
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An Overview of Stress Response and Hypometabolic Strategies in Caenorhabditis elegans: Conserved and Contrasting Signals with the Mammalian System
Benjamin Lant, Kenneth B. Storey
Int. J. Biol. Sci. 2010, 6: 9-50
[Abstract]
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Smad4-mediated TGF-β signaling in tumorigenesis
Guan Yang, Xiao Yang
Int. J. Biol. Sci. 2010, 6: 1-8
[Abstract]
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Physiological and Oncogenic Aurora-A Pathway
Toshiaki SAEKI, Mutsuko OUCHI, Toru OUCHI
Int. J. Biol. Sci. 2009, 5: 758-762
[Abstract]
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A receptor and binding protein interplay in the detection of a distinct pheromone component in the silkmoth Antheraea polyphemus
Maike Forstner, Heinz Breer, Jürgen Krieger
Int. J. Biol. Sci. 2009, 5: 745-757
[Abstract]
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Cloning, Expression and Purification of an Acetoacetyl CoA Thiolase from Sunflower Cotyledon
James H. Dyer, Anthony Maina, Iris D. Gomez, Melissa Cadet, Silke Oeljeklaus, Anke C. Schiedel
Int. J. Biol. Sci. 2009, 5: 736-744
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Identification of Anoectochilus based on rDNA ITS sequences alignment and SELDI-TOF-MS
Chuan Gao, Fusheng Zhang, Jun Zhang, Shunxing Guo, Hongbo Shao
Int. J. Biol. Sci. 2009, 5: 727-735
[Abstract]
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A Comparison of the Effects of Three GM Corn Varieties on Mammalian Health
Joël Spiroux de Vendômois, François Roullier, Dominique Cellier, Gilles-Eric Séralini
Int. J. Biol. Sci. 2009, 5: 706-726
[Abstract]
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The presence of alpha-catenin in the VE-cadherin complex is required for efficient transendothelial migration of leukocytes
Jaap D. van Buul, Floris P. van Alphen, Peter L. Hordijk
Int. J. Biol. Sci. 2009, 5: 695-705
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Role of Ldb1 in Adult Intestinal Homeostasis
Ipsita Dey-Guha, Mahua Mukhopadhyay, Matthew Phillips, Heiner Westphal
Int. J. Biol. Sci. 2009, 5: 686-694
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Proteome Changes in Thai Indigenous Chicken Muscle during Growth Period
Tawatchai Teltathum, Supamit Mekchay
Int. J. Biol. Sci. 2009, 5: 679-685
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Azithromycin suppresses interleukin-12p40 expression in lipopolysaccharide and interferon-γ stimulated macrophages
Keiko Yamauchi, Yoko Shibata, Tomomi Kimura, Shuichi Abe, Sumito Inoue, Daisuke Osaka, Michiko Sato, Akira Igarashi, Isao Kubota
Int. J. Biol. Sci. 2009, 5: 667-678
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Karyology of eight species of bats (Mammalia: Chiroptera) from Hainan Island, China
Yi Wu, Masaharu Motokawa, Yu-Chun Li, Masashi Harada, Zhong Chen, Liang-Kong Lin
Int. J. Biol. Sci. 2009, 5: 659-666
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Clinical diagnosis for discogenic low back pain
Yin-gang Zhang, Tuan-mao Guo, Xiong Guo, Shi-xun Wu
Int. J. Biol. Sci. 2009, 5: 647-658
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An apoA-I mimetic peptide facilitates off-loading cholesterol from HDL to liver cells through scavenger receptor BI
Xuelei Song, Paul Fischer, Xun Chen, Charlotte Burton, Jun Wang
Int. J. Biol. Sci. 2009, 5: 637-646
[Abstract]
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