International Journal of Biological Sciences

International Journal of Medical Sciences

Editor-in-Chief: Chuxia Deng, Mammalian Genetics Section, NIDDK, NIH
Editor-in-Chief's Profile

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This Journal is ranked among the top 2.1% of journals (29/1380) according to SCImago in the area of Agricultural and Biological Sciences ...details

Special Issue on Fish Stem Cells and Nuclear Transfer. Guest editor: Professor Yunhan Hong, Department of Biological Science, National University of Singapore

Most Cited Paper Award for 2007: The winner was JK Lunney, for the paper Advances in Swine Biomedical Model Genomics (Cited by 49 as of Dec. 31, 2009). Details ...

TAR DNA-binding Protein (TDP-43) and Fused in Sarcoma (FUS) are two conserved ribonucleoproteins and their mutant forms cause motor neuron degeneration, resulting in amyotrophic lateral sclerosis (ALS). To better understand the correlation of ALS disease genes with the selectivity of neurodegeneration, we thoroughly examined the longitudinal expression of the TDP-43 and FUS genes in rodents. TDP-43 and FUS were expressed robustly and ubiquitously during development, but were decreased markedly in adulthood. In adult animals, TDP-43 and FUS proteins were undetectable in most peripheral organs, but were maintained at substantial levels in the central nervous system. Motor neurons expressed these two genes robustly throughout the lifespan. In aged animals, TDP-43 and FUS were accumulated in the cytoplasm of motor neurons. Constant and robust expression of ALS disease genes may render motor neurons vulnerable to pathogenic mutation of the TDP-43 or the FUS gene. ...details

E2F-1 is the major cellular target of pRB and is regulated by pRB during cell proliferation. Despite the fact that E2F-1 and pRB have antagonistic activities when they are overexpressed, the role of the E2F-1-pRB interaction in cell growth largely remains unclear. In this study, we used E2F-1 mutants including E2F-1/S332-7A, E2F-1/S375A, E2F-1/S403A, E2F-1/Y411A and E2F-1/L132Q that have different binding affinities for pRB to understand the roles of the E2F-1 phosphorylation and E2F-1-pRB interaction in the cell cycle, as well as in transformation and gene expression. Data presented in this study suggests that although E2F-1 mutants 332-7, 375 and 403 showed similar binding affinity to pRB, they showed different characteristics in transformation efficiency, G0/G1 accumulation, and target gene experiments. Therefore, results suggest that E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity. ...details

Dengue viruses, mosquito-borne members of the Flaviviridae family, are the causative agents of dengue fever and its associated complications, dengue haemorrhagic fever and dengue shock syndrome. To date, more than 2.5 billion people in over 100 countries are at risk of infection, and approximately 20 million infections were reported annually. There is currently no treatment or vaccine available for dengue infection. This study employed a whole-cell organism model or in vitro methods to study the inhibitory property of the flavanoid-derived compounds against DENV2 activity. Results showed that at concentration not exceeding the maximum non-toxic dose (MNTD), these compounds completely prevented DENV2 infection in HepG2 cells as indicated by the absence of cytophatic effects. ...details

Previous studies revealed that leukocyte infiltration could trigger breast and prostate tumor invasion through physical disruption of tumor capsules. Our current study, involving multiple types of human tumors, further suggests that leukocyte infiltration also triggers metastasis through the following pathways: 1) the physical movement into the epithelium disrupts inter-cellular junctions and surface adhesion molecules, which cause the disassociation of tumor cells from tumor cores, 2) some of these tumor cells subsequently form tight junctions with the plasma membranes of leukocytes creating tumor cell-leukocyte chimeras (TLCs), and 3) the leukocytes of TLCs impart migratory capacity to associated tumor cell partners. Our findings suggest a novel pathway for tumor cell dissemination from primary sites and journey to new sites. ...details

IJBS issue cover

Research Paper
Smaller cardiac cell size and reduced extra-cellular collagen might be beneficial for hearts of Ames dwarf mice
Scott A. Helms, Gohar Azhar, Chunlai Zuo, Sue A. Theus, Andrzej Bartke, Jeanne Y. Wei
Int. J. Biol. Sci. 2010, 6: 475-490
[Abstract] [Full text] [PDF]

Review
Skeletal Muscle Stem Cells from Animals I. Basic Cell Biology
Michael V. Dodson, Gary J. Hausman, LeLuo Guan, Min Du, Theodore P. Rasmussen, Sylvia P. Poulos, Priya Mir, Werner G. Bergen, Melinda E. Fernyhough, Douglas C. McFarland, Robert P. Rhoads, Beatrice Soret, James M. Reecy, Sandra G. Velleman, Zhihua Jiang
Int. J. Biol. Sci. 2010, 6: 465-474
[Abstract] [Full text] [PDF]

Research Paper
Expression of Peptidylarginine Deiminase Type 4 in Ovarian Tumors
Lin Wang, Xiaotian Chang, Guangying Yuan, Yan Zhao, Pengcheng Wang
Int. J. Biol. Sci. 2010, 6: 454-464
[Abstract] [Full text] [PDF]

Research Paper
Catalpol Increases Brain Angiogenesis and Up-Regulates VEGF and EPO in the Rat after Permanent Middle Cerebral Artery Occlusion
Hui-Feng Zhu, Dong Wan, Yong Luo, Jia-Li Zhou, Li Chen, Xiao-Yu Xu
Int. J. Biol. Sci. 2010, 6: 443-453
[Abstract] [Full text] [PDF]

Research Paper
Increased invasiveness and aggressiveness in breast epithelia with cytoplasmic p63 expression
Yi-Hsuan Hsiao, Yan A. Su, Horng-Der Tsai, Jeffrey T. Mason, Ming-Chih Chou, Yan-gao Man
Int. J. Biol. Sci. 2010, 6: 428-442
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Fluorouracil Selectively Enriches Stem-like Leukemic Cells in a Leukemic Cell Line
Ling Zhang, Song Yang, Yu-Juan He, Hui-Yuan Shao, Li Wang, Hui Chen, Yu-Jie Gao, Feng-Xian Qing, Xian-Chun Chen, Liu-Yang Zhao, Shi Tan
Int. J. Biol. Sci. 2010, 6: 419-427
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Subtle evolutionary changes in the distribution of N-glycosylation sequons in the HIV-1 envelope glycoprotein 120
R. Shyama Prasad Rao, Bernd Wollenweber
Int. J. Biol. Sci. 2010, 6: 407-418
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Sustained Expression of TDP-43 and FUS in Motor Neurons in Rodent's Lifetime
Cao Huang, Pedro Yuxing Xia, Hongxia Zhou
Int. J. Biol. Sci. 2010, 6: 396-406
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
E2F-1 binding affinity for pRb is not the only determinant of the E2F-1 activity
Fikret Sahin, Todd L. Sladek
Int. J. Biol. Sci. 2010, 6: 382-395
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Proliferation of Myoblast Skeletal Cells on Three-Dimensional Supermacroporous Cryogels
Deepti Singh, Vijayashree Nayak, Ashok Kumar
Int. J. Biol. Sci. 2010, 6: 371-381
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Regulation of Vid-dependent degradation of FBPase by TCO89, a component of TOR Complex 1
Yan Yan, Bin Kang
Int. J. Biol. Sci. 2010, 6: 361-370
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Differential transcriptional analysis between red and white skeletal muscle of Chinese Meishan pigs
Yang Li, Zaiyan Xu, Hongying Li, Yuanzhu Xiong, Bo Zuo
Int. J. Biol. Sci. 2010, 6: 350-360
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Water Buffalo Genome Science Comes of Age
Vanessa N. Michelizzi, Michael V. Dodson, Zengxiang Pan, M Elisabete J Amaral, Jennifer J. Michal, Derek J. McLean, James E. Womack, Zhihua Jiang
Int. J. Biol. Sci. 2010, 6: 333-349
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Generation of Fgfr3 Conditional Knockout Mice
Nan Su, Xiaoling Xu, Cuiling Li, Qifen He, Ling Zhao, Can Li, Siyu Chen, Fengtao Luo, Lingxian Yi, Xiaolan Du, Haiyang Huang, Chuxia Deng, Lin Chen
Int. J. Biol. Sci. 2010, 6: 327-332
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Cloning, characterization, and expression analysis of goat (Capra hircus) phospholipid hydroperoxide glutathione peroxidase (PHGPx)
Li-guang SHI, Wen-juan XUN, Wen-bin YUE, Chun-xiang ZHANG, You-she REN, Qian WANG, Xiao-ying WU, Lei SHI, Ru-jie YANG, Fu-lin LEI
Int. J. Biol. Sci. 2010, 6: 316-326
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Survival of Escherichia coli under lethal heat stress by L-form conversion
Nadya Markova, Georgi Slavchev, Lilia Michailova, Mimi Jourdanova
Int. J. Biol. Sci. 2010, 6: 303-315
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Antiviral actions of flavanoid-derived compounds on dengue virus type-2
Mudiana Muhamad, Lee Yean Kee, Noorsaadah Abd. Rahman, Rohana Yusof
Int. J. Biol. Sci. 2010, 6: 294-302
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
Melatonin Plays a Protective Role in Postburn Rodent Gut Pathophysiology
Walid M. Al-Ghoul, Steven Abu-Shaqra, Byeong Gyu Park, Nadeem Fazal
Int. J. Biol. Sci. 2010, 6: 282-293
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Review
Notch and Wnt Signaling, Physiological Stimuli and Postnatal Myogenesis
Susan Tsivitse
Int. J. Biol. Sci. 2010, 6: 268-281
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Research Paper
NIP/DuoxA is essential for Drosophila embryonic development and regulates oxidative stress response
Xiaojun Xie, Jack Hu, Xiping Liu, Hanjuan Qin, Anthony Percival-Smith, Yong Rao, Shawn S.C. Li
Int. J. Biol. Sci. 2010, 6: 252-267
[Abstract] [Full text] [PDF] [PubMed] [PMC]