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Research Paper
The role of monoamine oxidase A in HPV-16 E7-induced epithelial-mesenchymal transition and HIF-1α protein accumulation in non-small cell lung cancer cells
Bingyu Huang, Zhiyuan Zhou, Jiao Liu, Xin Wu, Xiangyong Li, Qiang He, Peihua Zhang, Xudong Tang
Int. J. Biol. Sci. 2020; 16(14): 2692-2703. doi:10.7150/ijbs.46966
[Abstract] [Full text] [PDF]


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Review
The Role of Autophagy and Mitophagy in Bone Metabolic Disorders
Shuai Wang, Zhantao Deng, Yuanchen Ma, Jiewen Jin, Fangjie Qi, Shuxian Li, Chang Liu, Feng-Juan Lyu, Qiujian Zheng
Int. J. Biol. Sci. 2020; 16(14): 2675-2691. doi:10.7150/ijbs.46627
[Abstract] [Full text] [PDF]


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Research Paper
Encoding Method of Single-cell Spatial Transcriptomics Sequencing
Ying Zhou, Erteng Jia, Min Pan, Xiangwei Zhao, Qinyu Ge
Int. J. Biol. Sci. 2020; 16(14): 2663-2674. doi:10.7150/ijbs.43887
[Abstract] [Full text] [PDF]


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Research Paper
Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling
Yen-Ta Chen, Chi-Ruei Huang, Chia-Lo Chang, John Y. Chiang, Chi-Wen Luo, Hong-Hwa Chen, Hon-Kan Yip
Int. J. Biol. Sci. 2020; 16(14): 2648-2662. doi:10.7150/ijbs.48358
[Abstract] [Full text] [PDF]


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Review
miRNA-based biomarkers, therapies, and resistance in Cancer
Boxue He, Zhenyu Zhao, Qidong Cai, Yuqian Zhang, Pengfei Zhang, Shuai Shi, Hui Xie, Xiong Peng, Wei Yin, Yongguang Tao, Xiang Wang
Int. J. Biol. Sci. 2020; 16(14): 2628-2647. doi:10.7150/ijbs.47203
[Abstract] [Full text] [PDF]


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Research Paper
MiR-216a-5p inhibits tumorigenesis in Pancreatic Cancer by targeting TPT1/mTORC1 and is mediated by LINC01133
Jian Zhang, Shuohui Gao, Yandong Zhang, Huixin Yi, Mengxian Xu, Jialun Xu, HuanLiu, Zhichen Ding, Hongbin He, Hongmei Wang, Zhuo Hao, Liankun Sun, Yan Liu, Feng Wei
Int. J. Biol. Sci. 2020; 16(14): 2612-2627. doi:10.7150/ijbs.46822
[Abstract] [Full text] [PDF]


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Research Paper
Chidamide increases the sensitivity of Non-small Cell Lung Cancer to Crizotinib by decreasing c-MET mRNA methylation
Nan Ding, Abin You, Wei Tian, Liankun Gu, Dajun Deng
Int. J. Biol. Sci. 2020; 16(14): 2595-2611. doi:10.7150/ijbs.45886
[Abstract] [Full text] [PDF]


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Research Paper
Cancer stem cell property and gene signature in bone-metastatic Breast Cancer cells
An Luo, Yue Xu, Shujun Li, Jinxia Bao, Jinhui Lü, Nan Ding, Qian Zhao, Yuting Fu, Fei Liu, William C. Cho, Xunbin Wei, Haiyun Wang, Zuoren Yu
Int. J. Biol. Sci. 2020; 16(14): 2580-2594. doi:10.7150/ijbs.45693
[Abstract] [Full text] [PDF]


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Research Paper
Metformin suppresses inflammation and apoptosis of myocardiocytes by inhibiting autophagy in a model of ischemia-reperfusion injury
Kai-yu Huang, Jia-qun Que, Ze-song Hu, Yong-wei Yu, Ying-ying Zhou, Lei Wang, Yang-jing Xue, Kang-ting Ji, Xin-min Zhang
Int. J. Biol. Sci. 2020; 16(14): 2559-2579. doi:10.7150/ijbs.40823
[Abstract] [Full text] [PDF]


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Research Paper
Cancer-associated Fibroblasts induce epithelial-mesenchymal transition via the Transglutaminase 2-dependent IL-6/IL6R/STAT3 axis in Hepatocellular Carcinoma
Changchang Jia, Guoying Wang, Tiantian Wang, Binsheng Fu, Yincai Zhang, Lei Huang, Yinan Deng, Guanzhong Chen, Xiaocai Wu, Jianning Chen, Yuhang Pan, Yan Tai, Jinliang Liang, Xuejiao Li, Kunhua Hu, Bo Xie, Sujun Li, Yang Yang, Guihua Chen, Qi Zhang, Wei Liu
Int. J. Biol. Sci. 2020; 16(14): 2542-2558. doi:10.7150/ijbs.45446
[Abstract] [Full text] [PDF]


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Research Paper
Highly bioavailable Berberine formulation improves Glucocorticoid Receptor-mediated Insulin Resistance via reduction in association of the Glucocorticoid Receptor with phosphatidylinositol-3-kinase
Zhaojie Meng, Yang Yu, Yining Zhang, Xuehan Yang, Xiaoyan Lv, Fengying Guan, Grant M. Hatch, Ming Zhang, Li Chen
Int. J. Biol. Sci. 2020; 16(14): 2527-2541. doi:10.7150/ijbs.39508
[Abstract] [Full text] [PDF]


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Review
Immunoproteasome in IgA Nephropathy: State-of-Art and Future Perspectives
Ting Gan, Yang Li, Xu-jie Zhou, Hong Zhang
Int. J. Biol. Sci. 2020; 16(14): 2518-2526. doi:10.7150/ijbs.48330
[Abstract] [Full text] [PDF]


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Review
Insights into Nanomedicine for Immunotherapeutics in Squamous Cell Carcinoma of the head and neck
Qiang Xu, Meiyu Fang, Jing Zhu, Haoru Dong, Jun Cao, Lin Yan, Fransisca Leonard, Felix Oppel, Holger Sudhoff, Andreas M. Kaufmann, Andreas E. Albers, Xu Qian
Int. J. Biol. Sci. 2020; 16(14): 2506-2517. doi:10.7150/ijbs.47068
[Abstract] [Full text] [PDF]


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Research Paper
S-Palmitoylation as a Functional Regulator of Proteins Associated with Cisplatin Resistance in Bladder Cancer
Muhammad Shahid, Minhyung Kim, Peng Jin, Bo Zhou, Yang Wang, Wei Yang, Sungyong You, Jayoung Kim
Int. J. Biol. Sci. 2020; 16(14): 2490-2505. doi:10.7150/ijbs.45640
[Abstract] [Full text] [PDF]


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Review
Immune Response and COVID-19: A mirror image of Sepsis
Eduardo López-Collazo, José Avendaño-Ortiz, Alejandro Martín-Quirós, Luis A. Aguirre
Int. J. Biol. Sci. 2020; 16(14): 2479-2489. doi:10.7150/ijbs.48400
[Abstract] [Full text] [PDF]


Commentary
Glucocorticoids save lives in COVID-19 patients
Chu-Xia Deng
Int. J. Biol. Sci. 2020; 16(13): 2477-2478. doi:10.7150/ijbs.49125
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Cover image
Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau

Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10

Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Short Research Paper
Draft genome sequence of multi-resistant Salmonella enterica subsp. enterica serovar Rissen strain 19CS0416 isolated from Vietnam reveals mcr-1 plasmid mediated resistance to colistin already in 2013
Belen Gonzalez-Santamarina, Anne Busch, Silvia Garcia-Soto, Mostafa Y. Abdel-Glil, Jörg Linde, Reinhard Fries, Diana Meemken, Helmut Hotzel, Herbert Tomaso
J. Genomics 2020; 8: 76-79. doi:10.7150/jgen.42790
[Abstract] [Full text] [PDF]


Research Paper
Complete genome and plasmid sequences of a multidrug-resistant Salmonella enterica subsp. enterica serovar Panama isolate from a German cattle farm
Anne Busch, Helmut Hotzel, Ulrich Methner
J. Genomics 2020; 8: 71-75. doi:10.7150/jgen.48656
[Abstract] [Full text] [PDF]


Research Paper
crispRdesignR: A Versatile Guide RNA Design Package in R for CRISPR/Cas9 Applications
Dylan Beeber, Frédéric JJ Chain
J. Genomics 2020; 8: 62-70. doi:10.7150/jgen.41196
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft genome sequence of Actinomadura sp. K4S16 and elucidation of the nonthmicin biosynthetic pathway
Hisayuki Komaki, Enjuro Harunari, Natsuko Ichikawa, Akira Hosoyama, Moriyuki Hamada, Kannika Duangmal, Arinthip Thamchaipenet, Yasuhiro Igarashi
J. Genomics 2020; 8: 53-61. doi:10.7150/jgen.44650
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details