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Research Paper
Inhibition of PI3K/AKT signaling via ROS regulation is involved in Rhein-induced apoptosis and enhancement of oxaliplatin sensitivity in pancreatic cancer cells
Yuhui Liu, Chengjian Shi, Zheng He, Feng Zhu, Min Wang, Ruizhi He, Chunle Zhao, Xiuhui Shi, Min Zhou, Shutao Pan, Yang Gao, Xu Li, Renyi Qin
Int. J. Biol. Sci. 2021; 17(2): 589-602. doi:10.7150/ijbs.49514
[Abstract] [Full text] [PDF]


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Research Paper
Free CA125 promotes ovarian cancer cell migration and tumor metastasis by binding Mesothelin to reduce DKK1 expression and activate the SGK3/FOXO3 pathway
Qianyu Huo, Chen Xu, Yanhong Shao, Qin Yu, Lunhui Huang, Yunde Liu, Huijing Bao
Int. J. Biol. Sci. 2021; 17(2): 574-588. doi:10.7150/ijbs.52097
[Abstract] [Full text] [PDF]


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Review
Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities
Shuai Wang, Yanhan Dong, Anjing Gong, Huimin Kong, Jinning Gao, Xiaodan Hao, Yongmei Liu, Zibo Wang, Yuqiao Fan, Chengyu Liu, Wenhua Xu
Int. J. Biol. Sci. 2021; 17(2): 562-573. doi:10.7150/ijbs.48782
[Abstract] [Full text] [PDF]


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Review
Extracellular vesicles and pancreatitis: mechanisms, status and perspectives
Yu-Chen Jia, Yi-Xuan Ding, Wen-Tong Mei, Yu-Ting Wang, Zhi Zheng, Yuan-Xu Qu, Kuo Liang, Jia Li, Feng Cao, Fei Li
Int. J. Biol. Sci. 2021; 17(2): 549-561. doi:10.7150/ijbs.54858
[Abstract] [Full text] [PDF]


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Research Paper
A rapid screening classifier for diagnosing COVID-19
Yang Xia, Weixiang Chen, Hongyi Ren, Jianping Zhao, Lihua Wang, Rui Jin, Jiesen Zhou, Qiyuan Wang, Fugui Yan, Bin Zhang, Jian Lou, Shaobin Wang, Xiaomeng Li, Jie Zhou, Liming Xia, Cheng Jin, Jianjiang Feng, Wen Li, Huahao Shen
Int. J. Biol. Sci. 2021; 17(2): 539-548. doi:10.7150/ijbs.53982
[Abstract] [Full text] [PDF]


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Research Paper
The histone demethylase KDM2B regulates human primordial germ cell-like cells specification
Weiyan Yuan, Zhaokai Yao, Veeramohan Veerapandian, Xinyan Yang, Xiaoman Wang, Dingyao Chen, Linzi Ma, Chaohui Li, Yi Zheng, Fang Luo, Xiao-yang Zhao
Int. J. Biol. Sci. 2021; 17(2): 527-538. doi:10.7150/ijbs.55873
[Abstract] [Full text] [PDF]


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Research Paper
KIF11 promotes cell proliferation via ERBB2/PI3K/AKT signaling pathway in gallbladder cancer
Dang Wei, Bian Rui, Fan Qingquan, Cai Chen, Hu Yun ping, Song Xiaoling, Weng Hao, Gu Jun
Int. J. Biol. Sci. 2021; 17(2): 514-526. doi:10.7150/ijbs.54074
[Abstract] [Full text] [PDF]


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Research Paper
DGCR5 is activated by PAX5 and promotes pancreatic cancer via targeting miR-3163/TOP2A and activating Wnt/β-catenin pathway
Shi-lei Liu, Chen Cai, Zi-yi Yang, Zi-you Wu, Xiang-song Wu, Xue-feng Wang, Ping Dong, Wei Gong
Int. J. Biol. Sci. 2021; 17(2): 498-513. doi:10.7150/ijbs.55636
[Abstract] [Full text] [PDF]


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Research Paper
The association of Metabolic Syndrome and its Components with the Incidence and Survival of Colorectal Cancer: A Systematic Review and Meta-analysis
Fei Han, Guanghai Wu, Shuai Zhang, Judong Zhang, Yongjie Zhao, Jing Xu
Int. J. Biol. Sci. 2021; 17(2): 487-497. doi:10.7150/ijbs.52452
[Abstract] [Full text] [PDF]


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Review
Application of radiomics and machine learning in head and neck cancers
Zhouying Peng, Yumin Wang, Yaxuan Wang, Sijie Jiang, Ruohao Fan, Hua Zhang, Weihong Jiang
Int. J. Biol. Sci. 2021; 17(2): 475-486. doi:10.7150/ijbs.55716
[Abstract] [Full text] [PDF]


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Research Paper
17β-Estradiol promotes LC3B-associated phagocytosis in trained immunity of female mice against sepsis
Zhiheng Sun, Junxing Qu, Xiaoyu Xia, Yuchen Pan, Xinghan Liu, Huaping Liang, Huan Dou, Yayi Hou
Int. J. Biol. Sci. 2021; 17(2): 460-474. doi:10.7150/ijbs.53050
[Abstract] [Full text] [PDF]


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Research Paper
Development of a novel immune-related lncRNA signature as a prognostic classifier for endometrial carcinoma
Jinhui Liu, Jie Mei, Yichun Wang, Xucheng Chen, Jiadong Pan, Laigen Tong, Yan Zhang
Int. J. Biol. Sci. 2021; 17(2): 448-459. doi:10.7150/ijbs.51207
[Abstract] [Full text] [PDF]


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Research Paper
Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma
An Song, Yuanyuan Wu, Weiming Chu, Xueming Yang, Zaiou Zhu, Enshi Yan, Wei Zhang, Junbo Zhou, Xu Ding, Jie Liu, Hongxia Zhu, Jinhai Ye, Yunong Wu, Yang Zheng, Xiaomeng Song
Int. J. Biol. Sci. 2021; 17(2): 430-447. doi:10.7150/ijbs.54014
[Abstract] [Full text] [PDF]


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Research Paper
SOX13/TRIM11/YAP axis promotes the proliferation, migration and chemoresistance of anaplastic thyroid cancer
Jianing Tang, Zelin Tian, Xing Liao, Gaosong Wu
Int. J. Biol. Sci. 2021; 17(2): 417-429. doi:10.7150/ijbs.54194
[Abstract] [Full text] [PDF]


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Review
The role of miR-320 in glucose and lipid metabolism disorder-associated diseases
Hengzhi Du, Yanru Zhao, Zhongwei Yin, Dao Wen Wang, Chen Chen
Int. J. Biol. Sci. 2021; 17(2): 402-416. doi:10.7150/ijbs.53419
[Abstract] [Full text] [PDF]


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Research Paper
Spreading of pathological TDP-43 along corticospinal tract axons induces ALS-like phenotypes in Atg5+/- mice
Rui Zhang, Yongkang Chen, Xinxin Wang, Haiyan Tian, Han Liu, Zhi Xiang, Dan Qi, Jason H. Huang, Erxi Wu, Xuebing Ding, Xuejing Wang
Int. J. Biol. Sci. 2021; 17(2): 390-401. doi:10.7150/ijbs.53872
[Abstract] [Full text] [PDF]

Cover image

Editor-in-Chief: Chuxia Deng, PhD, Dean and Chair Professor, Faculty of Health Sciences, University of Macau
Editor-in-Chief's Profile

new Latest impact factor 4.858 according to 2020 release of JCR®.

🆘 The global battle against SARS-CoV-2 and COVID-19: Special issue on Coronavirus disease https://www.ijbs.com/v16i10
Postdoctoral Fellowship and Associateship available in Faculty of Health Sciences (FHS),University of Macau ...full details
Journal of Genomics articles:

Review
The Genetic Background of Central Serous Chorioretinopathy: A Review on Central Serous Chorioretinopathy Genes
Konstantinos Giannopoulos, Maria Gazouli, Klio Chatzistefanou, Anthi Bakouli, Marilita M Moschos
J. Genomics 2021; 9: 10-19. doi:10.7150/jgen.55545
[Abstract] [Full text] [PDF]


Research Paper
Draft Genome Sequence of Enterobacter sp. AS-1, a Potential Eurytrophic Recombination Host
Yuki Iwasaki, Yuya Itoiri, Sota Ihara, Hironaga Akita, Mamoru Oshiki, Zen-ichiro Kimura
J. Genomics 2021; 9: 6-9. doi:10.7150/jgen.53040
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Isolation, draft genome sequencing and identification of Enterobacter roggenkampii CCI9
Hironaga Akita, Yuya Itoiri, Noriyo Takeda, Zen-ichiro Kimura, Hiroyuki Inoue, Akinori Matsushika
J. Genomics 2021; 9: 1-5. doi:10.7150/jgen.46294
[Abstract] [Full text] [PDF] [PubMed] [PMC]


Research Paper
Draft Genome Sequences for the Frankia sp. strains CgS1, CcI156 and CgMI4, Nitrogen-Fixing Bacteria Isolated from Casuarina sp. in Egypt
Samira Mansour, Erik Swanson, Céline Pesce, Stephen Simpson, Krystalynne Morris, W. Kelley Thomas, Louis S. Tisa
J. Genomics 2020; 8: 84-88. doi:10.7150/jgen.51181
[Abstract] [Full text] [PDF] [PubMed] [PMC]

Top cited papers:
The amyloid precursor protein plus presenilin-1 (APP/PS1) mice are a frequently-used model for Alzheimer's disease studies (AD). However, the data relevant to which proteins are involved in inflammatory mechanism are not sufficiently well-studied using the AD mouse model. Using behavioral studies, quantitative RT-PCR and Western-blot techniques, significant findings were determined by the expression of proteins involved in inflammation comparing APP/PS1 and Wild type mice. Increased GFAP expression could be associated with the elevation in number of reactive astrocytes.. ....details
Recently, interest in IL-15-differentiated cells has increased; however, the phenotypic definition of IL-15-differentiated bone marrow-derived cells (IL-15-DBMCs) is still under debate, particularly the generation of IFN-γ-producing innate cells such as premature NK (pre-mNK) cells, natural killer dendritic cells (NKDCs), interferon-producing killer dendritic cells (IKDCs), and type 1 innate lymphoid cells (ILC1s), all of which are IL-15-dependent. Here, we revisited the immunophenotypic characteristics of IFN-γ-producing IL-15-DBMCs and their functional role in the control of intracellular Mycobacterium tuberculosis (Mtb) infection.. ....details
Bone marrow-derived progenitor cell-mediated vasculogenesis is a key process for vascular repair and regeneration. However, the role of androgens in the mechanism of ischemia-induced vasculogenesis remains unclear. In this study, a gender-mismatch murine bone marrow transplant model was used to allow tissue tracking of transplanted cells. Bone marrow from 2-month-old male mice was transplanted into irradiated age-matched female recipients. Following the transplantation, ovariectomized female recipients were subjected to unilateral hindlimb ischemia and immediately implanted with either dihydrotestosterone (DHT) or placebo pellets. Laser Doppler perfusion imaging revealed that DHT significantly augmented blood flow recovery, with increased capillary density compared to placebo-treated female recipient controls.. ....details
In this review, we describe the current progresses of cancer related exosomes, including their biogenesis, molecular contents, biological functions, sources where they are derived from, and methods for their detection. We will also discuss the current exosomal biomarkers and the utilization of them for early diagnosis and prognostics in cancer. ... ...details